Protease Inhibitors and Phosphatase Inhibitors
Medchemexpress LLC HY-108439 10mg Medchemexpress, Neurodazine CAS:937807-66-4 Purity:>98%
Medchemexpress, HY-108439 10mg Neurodazine CAS:937807-66-4 Neurodazine is an imidazole-based small molecule, serve as a promoter of neurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activating Wnt and Shh signaling pathways. Neurodazine selectively suppresses astrocyte differentiation of P19 cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
![Carbosynth LLC. Chymostatin, 100mg, Mixture of Type A, B, and C[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal X: L-leucyl (Type A), L-valyl (Type B), L-isoleucyl (Type C), MW: 610.72, Molecular formula: C31H42N6O7, CAS# 9076-44-2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501685844.jpg-250.jpg)
Carbosynth LLC. Chymostatin, 100mg, Mixture of Type A, B, and C[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal X: L-leucyl (Type A), L-valyl (Type B), L-isoleucyl (Type C), MW: 610.72, Molecular formula: C31H42N6O7, CAS# 9076-44-2
Synonyms: [(S)-1-Carboxy-2-phenylethyl]carbamoyl-a-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal, Application: Microbial Product Inhibitor for Chymotrypsin, Papain, and Cathepsin B/G, Storage Temperature: -20°C, References: H. Umezawa, T. Aoyagi, H. Morishima, S. Kunimoto, M. Matsuzaki, M. Hamada, and T. Takeuchi, J. Antibiotics, 23, 425 (1970). (Original), K. Tatsuta, N. Mikami, K. Fujimoto, S. Umezawa, H. Umezawa, and T. Aoyagi, J. Antibiotics, 26, 625 (1973). (Chem. Structure), L.A. Johnson, K.E. Moon, and M. Eisenberg, Biochim. Biophys. Acta, 953, 269 (1988). (Inhibitory Activity)
![Carbosynth LLC. Chymostatin, 25mg, Mixture of Type A, B, and C[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal X: L-leucyl (Type A), L-valyl (Type B), L-isoleucyl (Type C), MW: 610.72, Molecular formula: C31H42N6O7, CAS# 9076-44-2](https://assets.fishersci.com/TFS-Assets/CCG/product-images/501685845.jpg-250.jpg)
Carbosynth LLC. Chymostatin, 25mg, Mixture of Type A, B, and C[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-a-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal X: L-leucyl (Type A), L-valyl (Type B), L-isoleucyl (Type C), MW: 610.72, Molecular formula: C31H42N6O7, CAS# 9076-44-2
Synonyms: [(S)-1-Carboxy-2-phenylethyl]carbamoyl-a-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal, Application: Microbial Product Inhibitor for Chymotrypsin, Papain, and Cathepsin B/G, Storage Temperature: -20°C, References: H. Umezawa, T. Aoyagi, H. Morishima, S. Kunimoto, M. Matsuzaki, M. Hamada, and T. Takeuchi, J. Antibiotics, 23, 425 (1970). (Original), K. Tatsuta, N. Mikami, K. Fujimoto, S. Umezawa, H. Umezawa, and T. Aoyagi, J. Antibiotics, 26, 625 (1973). (Chem. Structure), L.A. Johnson, K.E. Moon, and M. Eisenberg, Biochim. Biophys. Acta, 953, 269 (1988). (Inhibitory Activity)
Cayman Chemical ADAMTS-5 InhIbItr 5mg
An inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1)
Cayman Chemical IKK2 InhIbItr VI 1mg
A potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM); used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses
Indofine Chemical Leupeptin Hemisulp, 90%, 25 Mg
LEUPEPTIN HEMISULPHATE 25 MG, Products for Life Science, Ac-Leu-Leu-argininal hemisulphate, 2 C20H38N6O4 . H2O4S, MW: 951.19, >90%, 103476-89-7, MFCD00037012
Medchemexpress LLC Boc-Pro-prolinal | 86925-97-5 | MFCD00890691 | 98.3% | 296.36 g/mol | C15H24N2O4 | 5 MG
Prolyl endopeptidase inhibitor 1 (Boc-Pro-prolinal) is a small-molecule inhibitor of prolyl endopeptidase (PEP) used in biochemical and pharmacological research. It displays high affinity (Ki = 15 nM) and has reported anti-amnesic effects in preclinical studies. The compound is supplied as a solid and as DMSO stock solutions, with recommended storage at -20°C for solid material and -80°C for long-term solvent stocks.
- High potency against prolyl endopeptidase (Ki = 15 nM).
- High purity (98.34%).
- Available as solid and as DMSO stock solutions.
- Supplied in research-scale quantities suitable for in vitro and preclinical studies.
- Storage instructions provided for solid and solvent formats.
CPC Scientific H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH (trifluoroacetate salt) 1MG
This peptide is derived from residues 14-21 of protein kinase C C2 (epsilonPKC C2). This peptide specifically inhibits epsilon-PKC by disrupting PKC binding to its receptor, RACK2. epsilonPKC mediated signal transduction plays a role in cell proliferation, differentiation, and apoptosis.SEQUENCE: H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH (trifluoroacetate salt)ONE-LETTER SEQUENCE: EAVSLKPTMOLECULAR FORMULA: C37H65N9O13MOLECULAR WEIGHT: 844.0STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [182683-50-7]SYNONYMS: PKC Inhibitor PeptideRESEARCH AREA: Protein Kinases and PhosphatasesREFERENCES:Lamy, C. et al. Tetrahedron Lett. 46, 6177 (2007)
Brandman, R. et al. J. Biol. Chem. 282, 4113 (2007)SKU(s): PPEP-004A
Cayman Chemical CAIX InhIbItr S4 5mg
A CAIX inhibitor (Ki = 0.007 µM for the recombinant human enzyme); selective for CAIX over CAI and CAII but does inhibit CAXII (Kis = 5.6, 0.55, and 0.002 µM, respectively); inhibits proliferation of HT-29 and MDA-MB-231, but not HCT116, cancer cells under anoxic conditions (IC50s = 20, 481, and >1,000 µM, respectively); reduces the number of lung metastases, but not primary tumor growth, in an MDA-MB-231 mouse xenograft model at 10 mg/kg
Cayman Chemical ALK5 InhIbItr IIhydrochLR 25mg
A selective inhibitor of the TGF-β type 1 receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively); used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription
Cayman Chemical CathepsIn L InhIbItr 25mg
A potent cathepsin L inhibitor (IC50 = 0.85 nM); selective for cathepsin L over calpain II and cathepsin B (IC50s = 184, and 85.1 nM, respectively); trypanocidal against T. brucei (ED50 = 45 nM); completely suppresses osteoclastic pit formation on femur slices isolated from bovine cortical bone at a concentration of 1 μg/ml; inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner
Cayman Chemical STAT5 InhIbItr 25mg
A cell-permeable, nonpetidic nicotinoyl hydrazone that selectively suppresses STAT5 by targeting its SH2 domain (IC50 = 47 µM against STAT5β SH2 domain EPO peptide binding activity)